Small ruminant macrophage polarization may play a pivotal role on lentiviral infection

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Small ruminant macrophage polarization may play a pivotal role on lentiviral infection

Small ruminant lentiviruses (SRLV) infect the monocyte/macrophage lineage inducing a long-lasting infection affecting body condition, production and welfare of sheep and goats all over the world. Macrophages play a pivotal role on the host's innate and adaptative immune responses against parasites by becoming differentially activated. Macrophage heterogeneity can tentatively be classified into ...

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Immunogenetics of Small Ruminant Lentiviral Infections

The small ruminant lentiviruses (SRLV) include the caprine arthritis encephalitis virus (CAEV) and the Maedi-Visna virus (MVV). Both of these viruses limit production and can be a major source of economic loss to producers. Little is known about how the immune system recognizes and responds to SRLVs, but due to similarities with the human immunodeficiency virus (HIV), HIV research can shed ligh...

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Hippocampus as part of the limbic system plays an important role in abused drugs-induced memory. The role of glutamate receptor within the hippocampal CA1 area in morphine-induced memory has also been postulated. Previous studies indicated that glutamate receptors exert their effects in part through the release of nitric oxide (NO). In the present study, the effects of intra-CA1 area injections...

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Hippocampus as part of the limbic system plays an important role in abused drugs-induced memory. The role of glutamate receptor within the hippocampal CA1 area in morphine-induced memory has also been postulated. Previous studies indicated that glutamate receptors exert their effects in part through the release of nitric oxide (NO). In the present study, the effects of intra-CA1 area injections...

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Caprine Arthritis-Encephalitis, Small Ruminant Lentivius Infection

Importance Caprine arthritis and encephalitis (CAE) is an economically important viral disease of goats. The caprine arthritis encephalitis virus (CAEV), a lentivirus; infects its hosts for life. Although most infections are subclinical, a minority of animals develops progressive, untreatable disease syndromes including polyarthritis in adults and encephalomyelitis in kids. This virus also caus...

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ژورنال

عنوان ژورنال: Veterinary Research

سال: 2013

ISSN: 1297-9716

DOI: 10.1186/1297-9716-44-83